ABSTRACT
Global travel and trade have been hit hard by the COVID-19 pandemic. Border closures have impacted both leisure and business travel. The socioeconomic costs of border closure are particularly severe for individuals living and working across state lines, for which previously unhindered passage has been curtailed, and daily commute across borders is now virtually impossible. Here, we examine how the periodic screening of daily cross-border commuters across territories with relatively low COVID-19 incidence will impact the transmission of SARS-CoV-2 across borders using agent-based simulation. We find that periodic testing at practical frequencies of once every 7, 14 or 21 days would reduce the number of infected individuals crossing the border. The unique transmission characteristics of SARS-CoV-2 suggest that periodic testing of populations with low incidence is of limited use in reducing cross-border transmission and is not as cost-effective as other mitigation measures for preventing transmission. © 2022 IEEE.